What is IgA deficiency?
Immunoglobulin A (IgA) is an antibody blood protein that’s part of your immune system. Your body makes IgA and other types of antibodies to help fight off sickness. Having an IgA deficiency means that you have low levels of or no IgA in your blood.
IgA is found in mucous membranes, mainly in the respiratory and digestive tracts. It is also found in saliva, tears, and breastmilk. A deficiency seems to play a part in asthma and allergies. Researchers have also linked IgA deficiency to autoimmune health problems. These are health problems that cause your body’s immune system to attack your body by mistake.
What causes IgA deficiency?
IgA deficiency is a health problem that is passed down through families in about 1 in 5 cases. This means it is genetic. In rare cases, it can be caused by medicines you are taking.
What are the symptoms of IgA deficiency?
Most people with an IgA deficiency don’t have any symptoms or health problems. This is because they usually have normal amounts of other immunoglobulins that fight off infections. Some people with an IgA deficiency are more likely to get frequent infections. These problems can include sinus, lung, and digestive infections. Some people with IgA deficiency also are more likely to have allergies. They may also have digestive and autoimmune problems, such as celiac disease, rheumatoid arthritis, Graves disease, or lupus.
How is IgA deficiency diagnosed?
If IgA deficiency runs in your family or you have some of the above health problems, you might be at risk. Blood tests are done to see if you have an IgA deficiency. Some people with mild symptoms may never know they have IgA deficiency.
How is IgA deficiency treated?
There is no cure for IgA deficiency. Immunotherapy is not a treatment that works well. You can take steps to lower your risk for illness or infection. These may include taking antibiotics when you get sick. If infections are ongoing (chronic), you may need to take antibiotics for a period of time.
What are possible complications of IgA deficiency?
Potential complications can include:
Can IgA deficiency be prevented?
IgA deficiency is a problem that may be passed down through your family, so you can’t do anything to prevent it. But you can limit the spread of germs and sickness by washing your hands often and staying away from large crowds. This is especially important to do during cold and flu season. Also talk with your healthcare provider about vaccines that may help prevent illness and when you should get them.
If you have IgA deficiency and are worried about the risks of passing it on to your children, talk with a genetic counselor.
Key points about IgA deficiency
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Immunoglobulin A (IgA) is an antibody that’s part of your immune system. IgA is found in mucous membranes, especially in the respiratory and digestive tracts. It is also found in saliva, tears, and breastmilk.
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IgA deficiency is a genetic health problem that can be passed down through families.
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Most people with an IgA deficiency don’t have any symptoms or health problems.
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There is no cure for IgA deficiency. Immunotherapy does not work well as a treatment.
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Complications for IgA deficiency include asthma, diarrhea, ear and eye infections, autoimmune diseases, and pneumonia.
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You can limit the spread of germs and illnesses by washing your hands often and staying away from large crowds.
Next steps
Tips to help you get the most from a visit to your healthcare provider:
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Know the reason for your visit and what you want to happen.
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Before your visit, write down questions you want answered.
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Bring someone with you to help you ask questions and remember what your provider tells you.
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At the visit, write down the name of a new diagnosis and any new medicines, treatments, or tests. Also write down any new directions your provider gives you.
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Know why a new medicine or treatment is prescribed and how it will help you. Also know what the side effects are.
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Ask if your condition can be treated in other ways.
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Know why a test or procedure is recommended and what the results could mean.
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Know what to expect if you do not take the medicine or have the test or procedure.
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If you have a follow-up appointment, write down the date, time, and purpose for that visit.
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Know how you can contact your healthcare provider if you have questions, especially after office hours or on weekends.
FAQs
Having an IgA deficiency means that you have low levels of or no IgA in your blood. IgA is found in mucous membranes, mainly in the respiratory and digestive tracts. It is also found in saliva, tears, and breastmilk. A deficiency seems to play a part in asthma and allergies.
What is the prognosis for IgA deficiency? ›
Outlook / Prognosis
The prognosis for people with selective IgA deficiency varies by the individual but tends to be good. However, some people may develop more severe diseases as a result of the condition than others.
How do you fix low immunoglobulin A? ›
Treatment. No specific treatment is available. Some people gradually develop normal levels of IgA without treatment. Treatment involves taking steps to reduce the number and severity of infections.
What level of IgA is concerning? ›
Low IgA (<0.8g/L)
Patients may have a slightly higher risk of gastrointestinal diseases (including coeliac disease), autoimmune disease, or a modest increase in the rate of superficial infections.
Is IgA deficiency rare? ›
In North America, it is the most common form of primary immunodeficiency (PI), estimated to affect 1 in 500 people. Many affected individuals have no symptoms and do not even know they have a deficiency until the lack of IgA is noted when they are being evaluated for another condition, such as celiac disease.
What are the most common symptoms in patients with IgA deficiency? ›
Most people with an IgA deficiency don't have any symptoms or health problems. There is no cure for IgA deficiency. Immunotherapy does not work well as a treatment. Complications for IgA deficiency include asthma, diarrhea, ear and eye infections, autoimmune diseases, and pneumonia.
What are the long term effects of IgA deficiency? ›
People with selective IgA deficiency are at increased risk of other long-term conditions. These include: Allergies and asthma. Rheumatoid arthritis.
What autoimmune disease is associated with IgA deficiency? ›
Autoimmune diseases have been observed in roughly 20 to 30% of patients with selective IgA deficiency. With selective IgA deficiency, allergic conjunctivitis, eczema, rhinitis, urticaria, food allergy, and asthma are commonly noted. There is an association of IgA deficiency with type 1 diabetes.
Does low IgA cause fatigue? ›
Symptoms of IgA Deficiency can include: Fatigue or unusual tiredness (the most common and frequent symptom) Susceptibility to infections. Pneumonia and respiratory infections.
How can I increase my IgA naturally? ›
Studies suggest that taking up a relaxation technique, avoiding chronic stress, getting enough sleep and moderate exercise, quitting cigarettes, and having a good sense of humor may also strengthen the immune response and increase IgA.
Having an IgA deficiency means that you have low levels of or no IgA in your blood. IgA is found in mucous membranes, mainly in the respiratory and digestive tracts. It is also found in saliva, tears, and breastmilk. A deficiency seems to play a part in asthma and allergies.
What autoimmune diseases cause low IgG? ›
Immunoglobulin A deficiency
| Diseases | IgG | IgE |
|---|
| Ataxia telangiectasia | ↓ | ↓ |
| Wiskott-Aldrich syndrome | n/↑ | n/↑ |
| 'Bare-lymphocyte syndrome' (MHC deficiencies) | n/↓ | n/↓ |
| SCID* | ↓↓ | ↓↓ |
6 more rowsWhat are the symptoms of an IgG deficiency?
- Sinus infections and other respiratory infections.
- Gastrointestinal infections.
- Ear infections.
- Pneumonia.
- Bronchitis.
- Infections that result in a sore throat.
- Rarely, severe and life-threatening infections.
Mayo Clinic doctors trained in immune system disorders have experience in caring for people with selective IgA deficiency and other primary immunodeficiency conditions.
Can you get disability for IgA deficiency? ›
If you are disabled because of an immune deficiency disorder, you may qualify for Social Security benefits (SSDI). Children who show primary immune deficiency disorders, as well as certain adults, may otherwise qualify for SSI.
What drugs cause IgA deficiency? ›
IgA deficiency may occur in association with the administration of drugs such as phenytoin, sulfasalazine, hydroxychloroquine, and d-penicillamine. IgA deficiency has also been described in association with partial deletion of the long arm of chromosome 18 (18q syndrome) or with a ring chromosome 18.
What is the bad prognosis in IgA nephropathy? ›
IgA nephropathy (IgAN) is the most common primary glomerular disease and is an important cause of renal failure. Approximately, 30–40% of patients progress to end-stage renal disease (ESRD) within 20 years.
Is IgA disease treatable? ›
There's no cure for IgA nephropathy, but medicines can slow how quickly it becomes worse. Some people need treatment to lower inflammation, reduce the spilling of protein into the urine and prevent the kidneys from failing. Such treatments may help the disease become not active, a state called remission.
